Macrophages clean up: efferocytosis and microbial control
نویسندگان
چکیده
منابع مشابه
Efferocytosis is impaired in Gaucher macrophages
Gaucher disease, the inherited deficiency of lysosomal glucocerebrosidase, is characterized by the presence of glucosylceramide-laden macrophages resulting from impaired digestion of aged erythrocytes or apoptotic leukocytes. Studies of macrophages from patients with type 1 Gaucher disease with genotypes N370S/N370S, N370S/L444P or N370S/c.84dupG revealed that Gaucher macrophages have impaired ...
متن کاملERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis.
BACKGROUND Efferocytosis is a process by which dead and dying cells are removed by phagocytic cells. Efferocytosis by macrophages is thought to curb the progression of atherosclerosis, but the mechanistic insight of this process is lacking. METHODS AND RESULTS When macrophages were fed apoptotic cells or treated with pitavastatin in vitro, efferocytosis-related signaling and phagocytic capaci...
متن کاملDefective efferocytosis by alveolar macrophages in IPF patients.
RATIONALE Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia. The pathogenicity of IPF has been widely investigated but still remains to be clarified. Efferocytosis, the specialized recognition and ingestion of apoptotic cells by phagocytes, is essential for the resolution of inflammation in the lungs and repair of injured tissues. Impaired efferocyto...
متن کاملEfferocytosis
Kumar and Birge introduce efferocytosis - the process by which dead or dying cells are engulfed and digested by phagocytes.
متن کاملPhytoremediation for Environmental Clean Up
Pollution is an undesirable change in the physical, chemical or biological characteristics of air, land and water that will waste or deteriorate our raw material resources. Modern technological innovations have increased pollution levels above the self cleaning capacities of the environment. In recent times, one of the major issues is the threat to human life from the progressive deterioration ...
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ژورنال
عنوان ژورنال: Current Opinion in Microbiology
سال: 2014
ISSN: 1369-5274
DOI: 10.1016/j.mib.2013.10.007